COMBINING HEPATIC PERCUTANEOUS PERFUSION WITH IPILIMUMAB PLUS NIVOLUMAB IN ADVANCED UVEAL MELANOMA (CHOPIN): STUDY PROTOCOL FOR A PHASE IB/RANDOMIZED PHASE II TRIAL

Abstract Background While immune checkpoint inhibition (ICI) has revolutionized the treatment of metastatic cutaneous melanoma, no standard treatments are available for patients with metastatic uveal melanoma (UM).Several locoregional therapies are effective in the treatment of liver metastases, such as percutaneous hepatic perfusion with melphalan

Abstract Rolling bearings working in oscillating applications often suffer from false brinelling and fretting corrosion that limit their service life.At present, the study of oscillation-induced failures is primarily dominated by a large number of sliding and bench tests.However, most of the previous work are not able to fully describe the two clos

This paper investigates the combined effect of radial magnetic field and viscous dissipation on entropy generation in horizontal co-axial cylinders of generalized Couette flow.The analytical solutions for velocity and temperature profiles are obtained and utilized to compute the entropy generation, Bejan number as well as the average entropy genera

Introducing Deep Learning has been successful in improving the performance of automated writer identification systems.However, using very large patch sizes as input to CNN consumes a lot of machine resources and requires a lot of training time.To overcome this problem, many researchers use resized images.In this paper, we will try to make a compara